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The stimulation of xenobiotic metabolism by progestational agents may represent an important pharmacological and toxicological property of progestational agents. We have also observed that progestational agents inhibit the formation of stable adducts of 7,8-benzoflavone (7,8-BF) and mammary DNA. These findings led us to investigate whether progestational agents and estrogens have similar or different effects on the growth of rat mammary tumors. We now have evidence to suggest that progestational agents inhibit tumor cell proliferation. As part of our molecular studies, we have observed that aromatase mRNA expression and enzymatic activity is elevated in mammary tumor cells from rats treated with estradiol. These observations suggested that estradiol may induce an increase in aromatase expression in mammary tumors. Progesterone and progestational agents have no effect on aromatase mRNA expression or on aromatase enzymatic activity. 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